The metalloproteinase adamts1 wiley online library. Adam metallopeptidase with thrombospondin type 1 motif, 18 elisa kits adamts18 encodes a member of the adamts a disintegrin and metalloproteinase with thrombospondin. Diseases associated with adamts6 include inguinal hernia and weillmarchesani syndrome. A disintegrin and metalloproteinase with thrombospondin motifs 6. Results are expressed as means sem n 5 6 animalsgroup. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrinlike domain, and a thrombospondin type 1 ts. Find diseases associated with this biological target and compounds tested against it in bioassay experiments. Adam metallopeptidase with thrombospondin type 1 motif, 18 rgn 32. Adam metallopeptidase with thrombospondin type 1 motif 6 imported.
Adamts2, adam metallopeptidase with thrombospondin type 1 motif 2 vertebrate orthologs 10 human ortholog adamts2, adam. Hutchinsongilford progeria syndrome hgps, progeria is an extremely rare premature and accelerated aging disease. It is secreted into the blood and degrades large vwf multimers, decreasing their activity. Valvular interstitial cells vics might be the key actors6 as they display. What is adam metallopeptidase with thrombospondin type 1 motif 6. Individual members of this family differ in the number of cterminal ts motifs, and. Adam metallopeptidase with thrombospondin type 1 motif 2. Adam metallopeptidase with thrombospondin type 1 motif, 1 adamts1 protein his tag. Adts9, adam metallopeptidase with thrombospondin type 1 motif, 9. Adam metallopeptidase with thrombospondin type i motif, 1 adamts1 that has both antiangiogenic and aggrecanase activity was dysregulated in many pathophysiologic circumstances. Identification of novel transcripts and noncoding rnas in.
Adamts2, a disintegrin and metalloproteinase with thrombospondin repeats, hpcpni, procollagen nproteinase. Adam metallopeptidase with thrombospondin type 1 motif 4. Adamts gene adam metallopeptidase with thrombospondin type 1 motif. Additionally, a lack of this enzyme may disrupt the normal development of the heart, resulting in. Help pages, faqs, uniprotkb manual, documents, news archive and biocuration projects. Individual members of this family differ in the number of cterminal ts. Adam metallopeptidase with thrombospondin type 1 motif, 1. Complete information for adamts6 gene protein coding, adam metallopeptidase with thrombospondin type 1 motif 6, including. Identification of hub genes, key pathways, and therapeutic a. Adamts2 a disintegrinlike and metallopeptidase reprolysin type with thrombospondin type 1 motif, 2 synonyms. Adamts9 is composed of a signal peptide, a propeptide, a metalloproteinase domain, a disintegrinlike domain, thrombospondin type 1 like repeats, a cysteinrich domain, a spacer domain, and a unique cterminal domain somerville et al. Search thousands of articles and collaborate with scientists around the globe. Adam metallopeptidase with thrombospondin type 1 motif, 17.
Hgps patients generally appear physiological aging including thin skin with hyperpigmented lesions, loss of subcutaneous fat, alopecia, osteoporosis and severe generalized arteriosclerosis, leading to myocardial infarction in most cases, and the mean age of. Purchase mouse adam metallopeptidase with thrombospondin type 1 motif, adamts elisa kit. Protease profiling of liver fibrosis reveals the adam. Human amniotic fluidderived mesenchymal cells from fetuses. From ncbi gene this gene encodes a member of the adamts a disintegrin and metalloproteinase with thrombospondin motifs protein family. This gene encodes a member of the adamts a disintegrin and metalloproteinase with thrombospondin motifs protein family. Adamts2 adam metallopeptidase with thrombospondin type 1 motif 2, authors. Adamts5 adam metallopeptidase with thrombospondin type 1.
Since the first discovery of adamts1, various reports have described its. Adam metallopeptidase with thrombospondin type 1 motif 7. Adamts3, adam metallopeptidase with thrombospondin type 1 motif 3 vertebrate orthologs 10 human ortholog. Adamts6 adam metallopeptidase with thrombospondin type 1 motif 6 is a protein coding gene. Adamts3 adam metallopeptidase with thrombospondin type 1 motif 3 hgnc alliance mus musculus house mouse. P 1, 2 understanding of the mechanisms of homeostasis or deterioration of av leaflet is critically important for management of valve disease in the clinical setting. Among its related pathways are metabolism of proteins and oglycosylation of tsr domaincontaining proteins. Adam metallopeptidase with thrombospondin type 1 motif, 3.
Decreased expression of the angiogenesis inhibitor adamts1 adam metallopeptidase with thrombospondin type 1 motif, 1 has previously been reported during prostate cancer progression. New insights into the molecular characteristics of pulmonary. Adamts9 adam metallopeptidase with thrombospondin type 1 motif 9 human gene id. Adam metallopeptidase with thrombospondin type 1 motif, 17 elisa kits adamts17 encodes a member of the adamts a disintegrin and metalloproteinase with thrombospondin. Diseases associated with adamts1 include bulbar polio and brownsequard syndrome. Other experimentally validated mir140 targets include adam metallopeptidase with thrombospondin type 1 motif 5 adamts5, aspartyl aminopeptidase dnpep and vral simian leukemia viral oncogene homolog a rasrelated rala 49, 59, 65. Adamts3 adam metallopeptidase with thrombospondin type 1. We evaluated the gene expression of other adamtss with. Study shows that the adamts6 transcript contains unusually large untranslated regions utrs at both the 5 and 3end, and the 5utr contains 11 aug codons upstream of the predicted adamts6 start codon. Adamts9 adam metallopeptidase with thrombospondin type 1.
Small bowel cancer, which accounts for merely 1 % to 2% of gastrointestinal malignant lesions, is an exceedingly rare malignancy considering that the small intestine comprises 75% of the length of the alimentary tract and 90% of its surface mucosal area. Gene ontology go annotations related to this gene include peptidase activity and metallopeptidase. Adamts2 is responsible for processing several types of procollagen proteins. Colorectal carcinoma is the 3rd most common morbidity and the 4th leading cause of cancer death in the world. Adam metallopeptidase with thrombospondin type 1 motif 6. However, there is limited information available on the transcriptional regulation of adamts1 gene. Adamts activity was similar in all 4 type i vwd cryodepleted plasmas and comparable to a normal control plasma.
After an injury, clots normally protect the body by sealing off damaged blood vessels and preventing further blood loss. Gene ontology go annotations related to this gene include heparin binding and metallopeptidase activity. Similarly, their altered expression was found in human. To investigate the expression of adam metallopeptidase with thrombospondin type i motif, 1 adamts1 in human prostate cancer, and to study its relationship to microvessel density mvd and. Adam metallopeptidase with thrombospondin type 1 motif, 4 elisa kits adamts4 encodes a member of the adamts a disintegrin and metalloproteinase with thrombospondin motifs protein family. Calorie restriction prevents dietinduced insulin resistance. The worlds first wiki where authorship really matters nature genetics, 2008. What is adam metallopeptidase with thrombospondin type 1 motif 3. Adamts6 adam metallopeptidase with thrombospondin type 1 motif 6 human.
The position of introns is indicated by a vertical line, splitting. The information on this page was automatically extracted from online scientific databases. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrinlike domain, and a thrombospondin type 1 ts motif. The gain of function studies indicated that adam metallopeptidase with thrombospondin type 1 motif 6 activate nr5a1 gene expression. For example, the keratin type ii gene cluster, pmel premelanosome protein, bloc1s1 biogenesis of lysosomal organelles complex1, subunit 1, kitlg kit ligand, and adamts20 adam metallopeptidase with thrombospondin type 1 motif 20 are located on bta5. A shortage of the adamts10 enzyme also interferes with the development and function of the lens of the eye, causing eye abnormalities and impaired vision. Adamts3 a disintegrinlike and metallopeptidase reprolysin type with thrombospondin type 1 motif, 3 mgi alliance. Next, we studied the expression of adam a disintegrin and metallopeptidase metallopeptidase with thrombospondin type 1 motif 1, an mr target gene involved in extracellular matrix remodeling with detrimental cardiovascular effects. The adamts2 gene is located on the long q arm of chromosome 5 at the end terminus of the arm, from base pair 178,473,473 to base pair 178,704,934 function. A disintegrin and metalloprotease with thrombospondin type i motif 7. Adamts6 adam metallopeptidase with thrombospondin type 1 motif 6 human this gene encodes a member of the adamts a disintegrin and metalloproteinase with thrombospondin motifs protein family. This gene encodes a member of the adamts a disintegrin and metalloproteinase with thrombospondin motif protein family.
Adamts1 adam metallopeptidase with thrombospondin type 1 motif 1 is a protein coding gene. Adam metallopeptidase with thrombospondin type 1 motif, 4. Adamts2 a disintegrinlike and metallopeptidase reprolysin. Adamts1 adam metallopeptidase with thrombospondin type 1. Procollagens are the precursors of collagens, the proteins that add strength and support to many body tissues specifically, this enzyme clips a short. Adam metallopeptidase with thrombospondin type 1 motif, 15 elisa kits adamts15 encodes a member of the adamts a disintegrin and metalloproteinase with thrombospondin. Human adam metallopeptidase with thrombospondin type 1. Members of the family share several distinct protein modules, including a propeptide region, a. Adamts5 adam metallopeptidase with thrombospondin type 1 motif 5 gene view the gene browser allows to navigate the human genome and investigate the relationship between pdb entries and genes. Capturebased targeted ultradeep sequencing in paired tissue. Adam metallopeptidase with thrombospondin type i motif, 18 adamts18, which typically acts as a tumorsuppressor, was recently found to be mutated in melanoma, and mutant adamts18 could increase melanoma cell migration and metastasis. A disintegrinlike and metallopeptidase reprolysin type with thrombospondin type 1 motif, 6.
Adam metallopeptidase with thrombospondin type 1 motif, 3 odriscoll et al. Protein target information for adam metallopeptidase with thrombospondin type 1 motif 6 tropical clawed frog. Several mutations unique to lcnec were reported by george et al. Individual members of this family differ in the number of cterminal. Adam metallopeptidase with thrombospondin type i motif, 1. Adamts5 encodes a member of the adamts a disintegrin and metalloproteinase with thrombospondin motifs protein family. The adam metallopeptidase with thrombospondin type 1 motif, 2 protein sequence is shown below the coding dna sequence, with numbering indicated at the right starting with 1 for the translation initiating methionine. Adamts4 adam metallopeptidase with thrombospondin type 1. Apr 15, 2019 this gene encodes a member of the adamts a disintegrin and metalloproteinase with thrombospondin motifs protein family.
The results means sem are expressed as arbitrary units per unit of 28s ribosomal rna in a percentage of the control wt mice. Data mining of pediatric medulloblastoma microarray. The adamts gene provides instructions for making an enzyme that is involved in blood clotting. Adamts a disintegrin and metalloproteinase with thrombospondin motifs protein family, cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. Genomic profiles of colorectal carcinoma with liver.
Adam metallopeptidase with thrombospondin type 1 motif 6 explanation free. Adamts1 adam metallopeptidase with thrombospondin type 1 motif, 1, authors. Adamts6 adam metallopeptidase with thrombospondin type 1. A disintegrin and metalloproteinase with thrombospondin motifs 3, adam ts 3, adam ts3, adamts3, pc iinp, a disintegrinlike and metalloprotease reprolysin type with thrombospondin type 1 motif, 3, procollagen ii nproteinase, procollagen ii amino propeptideprocessing enzyme, zinc metalloendopeptidase, adam metallopeptidase with. Oct 30, 20 furthermore, the ntd cells showed, compared with both healthy amniotic fluid cells and fetal fibroblasts, much lower mrna expression levels of genes that are involved in collagen biosynthesis procollagen cendopeptidase enhancer proteins pcolce, pcolce2, adam metallopeptidase with thrombospondin type 1 motif, 2 adamts2, adamts14. Adamtsag6 redirected from adam metallopeptidase with thrombospondin type 1 motif 6 adamtsag6 an adamtss family enzyme encoded by adamts6 on chromosome 5q12, which is expressed at low levels in placenta and barely detectable in other tissues. Adam metallopeptidase with thrombospondin type 1 motif, 2. Adamts1 a disintegrin and metalloprotease with thrombospondin motif 1.
Adam metallopeptidase with thrombospondin type 1 motif, 18 elisa kits adamts18 encodes a member of the adamts a disintegrin and metalloproteinase with thrombospondin motifs protein family. Imagine a global collaborative knowledge base for original thoughts. Identification of anaplastic lymphoma kinase as a potential. The deduced proteins contain 1,018 and 658 amino acids, respectively. Exons 1, 5, and 6 encode a proprotein domain, a disintegrinlike domain and a tsp type i motif, respectively, of the adamts1 protein.
Adam metallopeptidase with thrombospondin type 1 motif, 15. Adamts2 adam metallopeptidase with thrombospondin type 1. Adamts1 adam metallopeptidase with thrombospondin type 1 motif 1 human. Adamts2 belongs to the adam metallopeptidase with thrombospondin type 1 motif adamts family. Adam metallopeptidase with thrombospondin type 1 motif 6 is a protein that in humans is encoded by the adamts6 gene. Homologene, hgnc synonyms adam ts7, adam ts 7, adamts7. A disintegrinlike and metallopeptidase reprolysin type. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrinlike domain, and a thrombospondin type 1 ts motif. Fulllength adamtsl6alpha has an nterminal signal sequence, followed by an atypical thrombospondin type1 repeat tsr, a cysteinerich domain, an adamts spacer, 6 tandem tsrs, and a cterminal plac domain. Adamts1, a putative antiangiogenic factor, is decreased in. Looking for online definition of adam metallopeptidase with thrombospondin type 1 motif 3 in the medical dictionary. Stromaderived but not tumor adamts1 is a main driver of tumor growth and metastasis.
A metaanalysis of somatic mutations from next generation. Human ortholog adamts7, adam metallopeptidase with thrombospondin type 1 motif 7 orthology source. Advances in sequencing technologies have revealed tumor heterogeneity not only among different patients with the same type of cancer but also within an individual tumor. Breast cancer is the most common female malignancy and the second leading cause of cancerrelated death in the united states. However, this notion is refuted by the lack of effect. Among differentially expressed transcripts, we validated altered expression of integrin subunit alpha 2 itga2, adam metallopeptidase with thrombospondin type 1 motif 12, and st8 alphanacetylneuraminide alpha2,8sialyltransferase 5 in mouse wt and foxo3 ko colon and tumors p. Among its related pathways are metabolism of proteins and adhesion. Adam metallopeptidase with thrombospondin type 1 motif 3 explanation free. Meaning of adam metallopeptidase with thrombospondin type 1 motif 6 medical term.
Adam metallopeptidase with thrombospondin type 1 motif 1. Adamts1 protease is required for a balanced immune cell. Adam metallopeptidase with thrombospondin type 1 motif, 1 imported submitted name. Adam metallopeptidase with thrombospondin type 1 motif 2 inactivation reduces the extent and stability of carbon tetrachlorideinduced hepatic fibrosis in mice fred. Adamts18 gene adam metallopeptidase with thrombospondin type 1 motif 18. Adamts10 gene adam metallopeptidase with thrombospondin type 1 motif 10. Adamts family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrinlike domain, and a thrombospondin type 1 ts motif. Pdf adamts1 alters blood vessel morphology and tsp1 levels.
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